Binding Constants of Clinical Drugs and Other Organic Ligands with Human and Mammalian Serum Albumins

A dataset containing the experimental values of equilibrium binding constants clinical drugs, and some other organic ligands with human mammalian (predominantly bovine) serum albumins, is assembled. The affinity drugs to albumin governs their pharmacokinetic properties, related permeability through physiological barriers distribution within organism. contains 1755 records gathered from 346 original literature sources describing 324 different substances. data were extracted both articles existing protein-binding databases applied strict selection rules in order exclude influenced by third-party compounds. provides details on conditions measurements, such as temperature; protein ligand concentrations; buffer pH, composition concentration; method model used for constant calculations. Analysis reveals discrepancies between studies, well significant influence measurement method. Averaging multiple independent measurements may help determine reliable constants. can be reference development predictive models calculate constants, choice setup future albumin-binding studies.